Sorry for the lack of context. I am new to LabVIEW and even newer to Python so my issue here is more with coding in Python. I'm not sure how to code the python script to read in three individual channel values (One RTD temperature value and two pressure values). A coworker of mine wrote the code to accept data in from a simple data file instead of directly reading the measured values from LabVIEW. If I had to write the one temperature and two pressure values to an input text file, read these into Python from the input text file, write the result back to an output text file, and read the result back into LabVIEW from the output text file each iteration of my while loop, my LabVIEW control method would be highly inefficient. I'm trying to find a more efficient way of passing the three measurements to Python and receiving back the result. You can see the three channels I have wired into the Python Node as inputs in the code snippet from my last message. There has to be a way to read in values from specific instrumentation channels on the DAQ to Python, but I simply don't know how. Does that help you at all?