According to economic indicators, the recent financial crisis that started in 2008 had a profound impact on Europe and, in particular, on the Spanish population (Guardiola et al. 2015; Mndez et al. 2015). With negative growth of GDP (from 2009 to 2013) and alarming unemployment figures (peaking at 27 % as of January 2013), the risk of poverty and social exclusion has increased dramatically. It is estimated that 20 % of the Spanish population was below the poverty line in 2013, five points more than in 2004.Footnote 5 The severe material deprivation rate also rose from 4.8 in 2004 to 6.2 in 2013.Footnote 6 Our intention in this paper is to revisit the situation of the largest Spanish municipalities in terms of QoL in 2011 (i.e., 10 years after our previous study). For this purpose, we have carefully collected a comprehensive set of social and economic indicators covering all the relevant dimensions of QoL in 2011. This update may capture the impact of the crisis across the territory, not only in terms of GDP but also in terms of well-being.