Eliminar Programas Por Completo Windows 10

Like clockwork I can open Photoshop without a problem the first time. If I close PS6 and re-open it I am unable to Create a New File, Open any existing graphics or PS compatible files until I reboot again. Hitting CTRL-N shows me the new file dialogue which I can't get to show up from choosing File-->New. However, once I hit enter on the dialogue it goes away but no ned file is opened.