"Cherokee Rose" was written by Evan Reilly and directed by Billy Gierhart. Filming for the episode occurred in downtown Sharpsburg, Georgia on August 1, 2011. Preparation for filming initiated in July 2011, when producers converted an empty building into a temporary drug store.[2] Herb Bridges, who owned the building at the time, was first contacted by producers of the series' in January 2011, and again four months later in May. Bridges informed them that the space would be rented by a woman who would open a children's store there; however, she had not moved into the space yet.[2] This episode contains a scene in which Daryl searches for Sophia in an abandoned home. Filming for the scene transpired at an abandoned late-nineteenth century Gothic revival home in Senoia, Georgia.[3] Gregory Melton, the series' production designer, was the first crew member to locate the house. Melton took a picture of it with his cell phone, and sent the picture to creator Frank Darabont.[3] Darabont reacted positively to the image, and later wrote it in the episode's script.[3]