This started occurring yesterday on my first work from home day since updating to windows 11 on my home PC. I found an eyeball searing temporary fix, by turning on HDR for each display. I did notice the monitor that was refreshing was averaging 48hz while the display that was retaining the image (and would refresh maybe once every five minutes if I didn't force it) was 144hz continuously but I didn't check what the rate was when it was working, I was too busy catching up with my work delayed by my trouble-shooting and fighting off the searing migraine from terrible HDR implementation.