Thanks Alfred! The tip worked to get the dialog box to appear at startup. Selecting "Select All" then "Clear" corrects the issue, but once I copy a chart from Excel into Affinity Designer the shortcut keys seem to lock up again. I tried just editing using the document within AD, and all the shortcut keys work fine, but once I copy and paste from Excel into AD, the keys get locked again. I then have to go through the "Select All" and "Clear" option. Strangest thing. I haven't yet tried to copy/paste from a different app.