The KNIME Python Integration makes use of an existing Python, which is installed alongside KNIME Analytics Platform. As the KNIME Python Integration depends on certain Python packages, the Python installation needs to have these packages installed. Our recommended way to set up such a Python environment is to use the Anaconda Python distribution from Continuum Analytics. In this guide we describe how to install Python and the necessary packages using Anaconda, as well as how to configure the KNIME Python Integration.