The international guidelines on the management of CHB by the Asian Pacific Association for the Study of the Liver (APASL),19 the European Association for the Study of the Liver (EASL),20 and the American Association for the Study of Liver Diseases (AASLD)21 identify the main goal of therapy as improved survival and quality of life, preventing the progression of the disease, decompensation of cirrhosis, the need for liver transplantation and the development of HCC.