I initially created all of my presets with the headphone jack and in-ear monitors. When I got an FRFR powered speaker, I did this exactly; tweaked them for the speaker. I was told by someone here that it's best to just start from scratch with the speaker, but with some time and patience, I got those patches sounding pretty great eventually. If you get a powered speaker that doesn't have "monitor mode" you'll need to get a mounting pole or an amp stand to avoid floor coupling. And as has been said, be sure to tweak at the approximate volume you'll be using at a live gig. Venues can vary wildly; that's what the global EQ is for.