At this writing (October 2018), Office 365 is roughly equivalent to Office 2016 with additional feature updates, but sold on a subscription rather than as a one-time purchase. Thus the rule is the same as for Office 2016: the Palisade version must be 7.0.0 or newer, and Office must be a full local install on the same PC, laptop, or server with the Palisade end-user applications. (Mac users will need to use a Windows virtual machine; see @RISK on the Apple Mac.) If your Office is set up to be accessed through a Web browser or your phone, it's not compatible with Palisade software.