If you delete the Cura folders under AppData Local and Roaming you essentially have a new install of Cura (unless there are damaged or missing files in your original install)
You can try opening Cura after you have removed these files and see if it will open. You might try running it as Administrator.
I have sometimes had a problem where it won't start from the original shortcut so I usually try running it from a variety of other shortcuts (Start Menu, taskbar or direct from installation location) In most cases it eventually starts. If you get Cura reporting that it has a configuration error and it wants to reset it for you, this will delete any settings and profiles you have already set up. It does, however, create a zipped backup of your old directory that you can access if you need to.
If you think your Cura installation is a problem and you just want to start fresh (not worrying about saving old settings and profiles) I would delete the two AppData Local and Roaming folders and then uninstall Cura. This would ensure that all Cura associated files have been removed and there should be no conflicts with old files.
I'm not sure of the purpose behind adjusting the Privacy Settings but if they are a problem maybe unchecking both would be better?
On an additional note, rather than deleteing the two Cura folders you may want to temporarily move the Roaming one (maybe drop it on your desktop) so you don't lose any profiles you might want later. The Local one, AFAIK, is used as a cache so it doesn't really matter for this.