By default, the PDF opens with the page layout specified in Preferences. However, if a different page layout is set in document Properties ( > Properties > Initial View), it will override the Preferences setting. If you want to use document properties, make sure to save and close the document for the changes to take effect. Please note that Acrobat users have the ability to change the initial view, unless there are security settings in place preventing changes. However, Acrobat Reader users can't change the initial view.