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Throughout the lifespan of a product changes can occur - ranging from small adjustments to the manufacturing and storage method, to formula changes. You will need to consult with your safety advisor as to whether a change is considered significant enough - such as a reformulation - to require the production of a new PIF. Changes of raw materials batches and suppliers will inevitably occur between batches of your product. Whilst it is in most cases unlikely that this would require a new PIF to be created, the exact batches of each raw material, associated documents (e.g. CoA and MSDS) as well as supplier information must be traceable to each and every batch of your product. This is best achieved by producing batch reports/protocols which serve as 'snapshots' of your product's batches and serve as supplements to your main PI file.