My impression is that this is a software issue with the "another pc." I suggest you Uninstall all Line 6 Helix software from the "another pc." Then Download and Reinstall HX Edit for Win10 from the Line 6 site. The clean reinstall of HX Edit 2.52 should reinstall the necessary drivers, Line 6 Updater 1.14, Helix Firmware 2.53 and Helix Edit 2.52 to this "another pc." Then use the Line 6 provided Helix USB cable on the main Buss connected USB port of the "another pc" -- not a remote USB port nor USB Hub.