The choice between RabbitMQ and MSMQ largely depends on the specific requirements of a project. RabbitMQ is a more flexible and scalable option, suitable for complex messaging patterns and cross-platform environments. MSMQ, on the other hand, is a good choice for Windows-based applications, particularly where offline messaging and transactional capabilities are important. Understanding the strengths and limitations of each can help in selecting the right message queuing solution for your needs.