During his final years, Hughes extended his financial empire to include several major businesses in Las Vegas, such as real estate, hotels, casinos, and media outlets. Known at the time as one of the most powerful men in the state of Nevada, he is largely credited with transforming Las Vegas into a more refined cosmopolitan city. After years of mental and physical decline, Hughes died of kidney failure in 1976. His legacy is maintained through the Howard Hughes Medical Institute and the Howard Hughes Corporation.[8]