Pluma published his second studio album, Efectos Secundarios, on 19 March 2021, preceded by the singles "Con Dinero Baila el Perro" and "Lo Que Me Das", a music video for the latter, as well as songs with previous collaborators El Choforo and Hector Rubio.[23] Focusing on building his sound, Pluma issued the single "Por Las Noches" on 11 June, a slowed-down sierreo track about an unintended breakup.[2][14] Pluma's "Todo Es Playa", a song about smoking marijuana, was his last single with El Cartel de los ngeles before he switched labels to Prajin Records under George Prajin.[22][25] To mark this shift, the singer published the socio-political track "Spiral" on 25 November.[22]