Rapid diagnostic tests (RDTs) based on the histidine-rich proteins 2 and 3 (HRP2 and HRP3) of the malaria parasite play a vital role in malaria diagnosis and have replaced microscopy as the laboratory confirmatory tool for clinical diagnosis in most malaria-endemic countries. However, natural deletions of hrp2 and hrp3 genes encoding these proteins can undermine the practical utility of current RDTs, which cannot detect HRP-deleted parasites, leading to false negatives.