I have multiple Win 10 PCs, two of which are desktops I built from scratch. Both were built together and upgraded to Win 10 at the same time, both with auto-update enabled on the exact same schedule. The hardware is essentially identical, but more importantly, the keyboard and mouse were the exact same. Yet one PC lost mouse response. I used the PC in the morning working on a PowerPoint presentation, stepped away for a hour, then came back to find my mouse was not working. I was using a Logitech M530 with a K350 Keyboard via a single USB unifying receiver. The keyboard was still working, but the mouse was not. I took out the batteries and tested them, and both were good, but I still switched out for new batteries. Nothing. I switched USB ports. Nothing. Then I took out a different USB wireless mouse and connected it. Nothing. I then went old school and pulled out a corded PS/2 mouse and connected it. Nothing. I rebooted...multiple times during many of these efforts. Nothing. After over an hour of messing around, including reloading the Logitech software, I still had nothing.