I'm on a Mac Ultra (13.2.1) but without the latest upgrade while waiting to ensure that CrossOver and GTA 5 will still work after the upgrade.
My ver of CO is also 22.1.1 and I'm playing GTA 5 just fine. In fact it's possible that the memory management has made it a bit better. I say a bit as I had a crash after an explosion at O'Neil's farm, but worked on the 2nd play through. My Xbox controller is a model 1797 (Elite Series 2).