Strangers follows Isobel, played by Zo Chao, a woman who finds herself unable to make rent once her boyfriend moves out after discovering she's cheated on him with a woman. To make up the cost, Isobel rents out her spare room on a fictionalized version of Airbnb, introducing a rotating cast of characters who each touch Zo with the fleeting intimacy of home-sharing. (They are the titular Strangers of the series.) With each new guest, Zo comes to learn something about herself as her sexuality and dreams of ditching her mommy blog editing job to become a real writer come into focus.