From the Desktop Configuration screen you can swap button bindings, change how the touchpad works (it can do separate left- and right-clicks) and also configure the gyroscope, if you want to use gyro aiming. You can also configure Action Sets and Action Layers to enable totally different button bindings and then switch to them on the fly in-game. For example, if you only wanted to use gyro controls while in a plane in GTA, you could create an Action Set for that and trigger it by pressing a specific key anytime you hop in a plane.