My desire to use this card was based on finding a card that can be adapter to a PCI-e slot and would function under a UEFI bios with secure boot, as I eventually wat to go to Windows 11. I have the card plugged into a Cardbus to PCCard adapter, which is in turn plugged into a PCI-e to PCCard adapter. Both adapters were purchased on Ebay at under $30. The 1480 does not have a bios, so there is no conflict with the UEFI bios of my mother board. I was initially using a Firewire to Scsi adapter to run the scanner. This initially worked fine, but after a while, I started having communication errors, potentially a component on the adapter was failing/overheating. The 1480 with Vuescan seems to be working well. With respect to modern motherbaord compatibility, this approach seems to be the only approach to install SCSI on motherboards without PCI slots that dose not require case modifications. The 2904 and 2906 cards, which too lack bios are likely compatible with UEFI, but these cards require a PCI-e to PCI riser to use in modern motherboards, which in turn requires a case modification due to the riser.