In 2060, Mitchell, Cormack, Ilona, and Knox (Khary Payton) infiltrate Irons' private residence in Bangkok. The team discovers that Danois is collaborating with Irons to produce a bio-weapon called "Manticore". They track and intercept a plane carrying Manticore bound for Argentina, which crashes in Antarctica. Gideon helps the Sentinels defeat the Atlas soldiers, allowing them to retrieve a sample of Manticore. They discover that the weapon is designed to attack the specific DNA of an individual and kill them; the only exceptions are Atlas members. Sentinel and Gideon infiltrate and destroy an Atlas bio-weapons laboratory in Bulgaria, destroying many Manticore samples. With his plan revealed, Irons declares war on the United Nations General Assembly, believing that the world would be better off without wars if Atlas were in control. The team discovers that, despite destroying the laboratory, Irons is planning a preemptive strike on the United States via an Atlas attack in San Francisco. Atlas destroys the Golden Gate Bridge, trapping the United States Navy's Third Fleet in the Bay Area in an attempt to destroy them, but are stopped by Sentinel forces. The United States and the rest of the world declare war on Atlas, forcing Irons to retreat to his headquarters in New Baghdad.