In HSV-2 seropositive persons who have symptomatic genital herpes but not HIV, suppressive antiviral therapy (e.g., valacyclovir 500 mg once daily) reduced HSV-2 transmission to susceptible heterosexual partners by 48%.22 However, in HIV-1/HSV-2-seropositive persons not on antiretroviral therapy (ART), suppressive acyclovir (400 mg twice daily) did not prevent HSV-2 transmission to HSV-2 seronegative partners.23 Suppressive anti-HSV therapy to prevent HSV-2 transmission to susceptible partners is not recommended for persons with HIV/HSV-2 coinfection who are not on ART (AI). There are no data available regarding use of suppressive therapy to prevent genital HSV-1 transmission.