While investigating a distress call, the crew of the Kellion are attacked by Necromorphs, creatures made from mutated human corpses, and separated. Isaac is forced to fend for himself as he tries to save his crewmates and learn the truth behind the loss of the Ishimura. Along the way, he encounters several survivors, including his girlfriend, Senior Medical Officer Dr. Nicole Brennan, horticulturalist and Hydroponics Director Dr. Elizabeth Cross, Cross's boyfriend and Acting Chief Engineer Jacob Temple, Chief Science Officer Terrence Kyne, and his colleague, Special Researcher Dr. Challus Mercer.[3][4][5]