Depending on your Citrix version, you may experience problems when launching Chrome. Besides the issue with the command line switches as described in the previous paragraph, you may also need to add the executables chrome.exe and nacl64.exe to the exclusion list for hooks injection as described in the Chromium article Run Chrome as a virtual application and the Citrix article How to Disable Citrix API Hooks on a Per-application (CTX107825). The official bug report (Chromium) can be read here: =432595.