Yes, it is safe to clean vinyl window frames. Vinyl is a durable material that is resistant to most cleaning chemicals. To clean vinyl window frames, all you need is a mild cleaning solution, such as dish soap and water, and a soft cloth. Avoid using solvents or abrasive cleaning materials that can scratch or damage the vinyl surface. You can add some vinegar to the cleaning solution to disinfect and remove stubborn stains or mildew. Cleaning your vinyl window frames regularly will keep them looking their best and help prolong their lifespan.