To activate the ColorPick Eyedropper extension, simply click on its icon located in the Chrome toolbar. This action initiates the extension and allows you to interact with the webpage, inspecting various elements using your cursor. As you hover over different sections or elements within the webpage, the extension provides you with real-time color previews. When you have identified the element and pixel that you want to extract the color from, simply click on it. ColorPick Eyedropper then captures the color at that precise pixel and provides you with the color value in your preferred format, such as RGB, HEX, or HSL.